TX:
-Anticoagulation
-Early mobilization. “Ambulation should be encouraged as soon as is feasible.” UTD
-PCDs
Common Causes of inherited hypercoagulable states
- Factor V Leiden mutation
- Prothrombin gene mutation
- Protein S deficiency
- Protein C deficiency
- Antithrombin deficiency
The most frequent causes of an inherited (primary) hypercoagulable state are the factor V Leiden mutation and the prothrombin gene mutation, which together account for 50 to 60 percent of cases. Defects in protein S, protein C, and antithrombin account for most of the remaining cases
Risk factors (causes) for the development of venous thrombosis
| Inherited thrombophilia |
| Factor V Leiden mutation |
| Prothrombin gene mutation |
| Protein S deficiency |
| Protein C deficiency |
| Antithrombin (AT) deficiency |
| Acquired disorders |
| Malignancy |
| Presence of a central venous catheter |
| Surgery, especially orthopedic |
| Trauma |
| Pregnancy |
| Oral contraceptives |
| Hormone replacement therapy |
| Tamoxifen, Thalidomide, Lenalidomide |
| Immobilization |
| Congestive failure |
| Antiphospholipid antibody syndrome |
| Myeloproliferative disorders |
| Polycythemia vera |
| Essential thrombocythemia |
| Paroxysmal nocturnal hemoglobinuria |
| Inflammatory bowel disease |
| Nephrotic syndrome |