http://www.aafp.org/afp/2014/0201/p180.html

Healthy Patient with a non-severe salmonella infection.

“A 52-year-old healthy male presents with a 2½-week history of diarrhea, consisting of 4–6 watery stools daily. He is afebrile and his examination is normal. You recommend symptomatic care. Two days later the laboratory notifies you that Salmonella is growing in his stool culture. You call the patient and he remains free of fever but with ongoing diarrhea.

What should you do? No treatment

The recommended management for patients who have non-severe Salmonella infection and are otherwise healthy is no treatment.

Patients with high-risk conditions that predispose to bacteremia, and those with severe diarrhea, fever, and systemic toxicity or positive blood cultures should be treated with levofloxacin, 500 mg once daily for 7–10 days (or another fluoroquinolone in an equivalent dosage), or with a slow intravenous infusion of ceftriaxone, 1–2 g once daily for 7–10 days (14 days in patients with immunosuppression).

Ref: DuPont HL: Acute infectious diarrhea in immunocompetent adults. N Engl J Med 2014;370(16):1532-1540.” ABFM

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