Table from uptodate.com
| Vascular | Cardiovascular disease, hypertension, diabetes mellitus, hyperlipidemia, smoking, major surgery (radical prostatectomy) or radiotherapy (pelvis or retroperitoneum) |
| Neurologic | Spinal cord and brain injuries, Parkinson disease, Alzheimer disease, multiple sclerosis, stroke |
| Local penile (cavernous) factors | Peyronie’s disease, cavernous fibrosis, penile fracture |
| Hormonal | Hypogonadism, hyperprolactinemia, hyper- and hypothyroidism, hyper- and hypocortisolism |
| Drug-induced | Antihypertensives, antidepressants, antipsychotics, antiandrogens, recreational drugs |
| Psychogenic | Performance-related anxiety, traumatic past experiences, relationship problems, anxiety, depression, stress |
- ED is classified as organic (ie, vasculogenic, neurogenic, local penile [cavernous] factors, hormonal, drug-induced), psychogenic, or mixed psychogenic and organic.
- ED usually develops from a mix of psychogenic and organic factors.
- Psychological factors are involved in the development of ED and include performance-related issues (eg, performance anxiety), traumatic past experiences, relationship problems, anxiety, depression, and stress.