The National Kidney Foundation and the KDIGO CKD guidelines define CKD as:
–GFR <60 mL/min per 1.73 m2 for at least 3 months
OR
-Other evidence of kidney damage such as 1) albuminuria, 2) abnormal kidney imaging, or 3) abnormal kidney biopsy for 3 months or more with implications for health.
Severe Chronic Kidney Disease
Thresholds used to define severe chronic kidney disease include:
- an eGFR <30 mL/min/1.73 m2,
- a urine albumin to creatinine ratio >300 µg/mg,
- persistent acidosis or potassium imbalance,
- non–iron deficiency anemia with a hemoglobin level <10 g/dL, and
- evidence of secondary hyperparathyroidism.
End-stage renal disease (kidney failure)
- GFR below 15 mL per minute per 1.73 m2, OR
- Need for kidney replacement therapy (dialysis or transplant)
Further Reading / References
Ann Intern Med. 2013 Jun 4;158(11):825-30. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. https://www.ncbi.nlm.nih.gov/pubmed/23732715
Am J Med. 2016 Feb;129(2):153-162.e7. Practical Approach to Detection and Management of Chronic Kidney Disease for the Primary Care Clinician. https://www.ncbi.nlm.nih.gov/pubmed/26391748