Rome III diagnostic criteria for functional dyspepsia.
According to the 2006 Rome III criteria, functional dyspepsia is divided into two subgroups: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS).
| At least 3 months, with onset at least 6 months previously, of one or more of the following: |
| • bothersome postprandial fullness |
| • early satiation |
| • epigastric pain |
| • epigastric burning |
| AND |
| • no evidence of structural disease (including upper endoscopy) that is likely to explain the symptoms |
Rome III diagnostic criteria for postprandial distress syndrome.
| At least 3 months, with onset at least 6 months previously, with one or both of the following symptoms. |
| 1. Bothersome postprandial fullness, occurring after ordinary-sized meals, at least several times per week. |
| 2. Early satiation that prevents finishing a regular meal, at least several times per week. |
| • Supportive criteria |
| 1. Upper abdominal bloating or postprandial nausea or excessive belching can be present. |
| 2. May coexist with epigastric pain syndrome. |
Rome III diagnostic criteria for epigastric pain syndrome.
| At least 3 months, with onset at least 6 months previously, with ALL of the following symptoms: |
| 1. Pain or burning localized to the epigastrium of at least moderate severity, at least once per week. |
| 2. Pain is intermittent. |
| 3. Pain is not generalized or localized to other abdominal or chest regions. |
| 4. Pain is not relieved by defecation or passage of flatus. |
| 5. Pain does not fulfill criteria for gallbladder or sphincter of Oddi disorders. |
| • Supportive criteria |
| 1. Pain may be of a burning quality, but without a retrosternal component. |
| 2. Pain is commonly induced or relieved by ingestion of a meal, but may occur while fasting. |
| 3. Pain may coexist with postprandial distress syndrome. |
Definitions of functional dyspepsia symptoms.
| Symptom
|
Definition
|
|---|---|
| Epigastric pain | Epigastric refers to the region between the umbilicus and lower end of the sternum, and marked by the midclavicular lines. Pain refers to a subjective, unpleasant sensation; some patients may feel that tissue damage is occurring. |
| Epigastric burning | Epigastric refers to the region between the umbilicus and lower end of the sternum, and marked by the midclavicular lines. Burning refers to an unpleasant subjective sensation of heat. |
| Postprandial fullness | An unpleasant sensation like the prolonged persistence of food in the stomach. |
| Early satiation | A feeling that the stomach is overfilled soon after starting to eat, out of proportion to the size of the meal being eaten, so that the meal cannot be finished. Previously, the term ‘early satiety’ was used, but satiation is the correct term for the disappearance of the sensation of appetite during food ingestion. |
Reference
Brun R, Kuo B. Functional dyspepsia. Therapeutic Advances in Gastroenterology. 2010;3(3):145-164. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002577/