| Drug |
Initial Dose |
Titration Dose |
Minimum Interval Before Dose Adjustment |
MaxDose
|
| Bumetanide |
1 mg bolus, then 0.5 mg/hr |
0.5mg/hr |
Q 60 min |
2 mg/hr |
| Clevidipine |
1 mg/hr |
1 mg/hr |
Q 15 min |
10 mg/hr |
| Dexmedetomidine (Precedex) |
1 mcg/kg over 10 min bolus, then 0.2 mcg/kg/hr |
0.1 mcg/kg/hr |
Q 10 min |
0.7 mcg/kg/hr, Target RASS (-)2 |
| Diltiazem |
10 mg bolus, then 5 mg/hr |
2.5 mg/hr |
Q 15 min |
15 mg/hr |
| DoBUTamine |
2 mcg/kg/min |
2 mcg/kg/min |
Q 10 min |
40 mcg/kg/min |
| DOPamine |
2 mcg/kg/min |
2 mcg/kg/min |
Q 5 min |
30 mcg/kg/min |
| Epinephrine |
5 mcg/min (0.005 mcg/kg/min) |
5 mcg/min (0.001 mcg/kg/min) |
Q 3-5 min |
30 mcg/min (0.05 mcg/kg/min) |
| Esmolol |
50 mcg/kg/min |
50 mcg/kg/min |
Q 4-5 min |
200 mcg/kg/min |
| Fentanyl |
25 mcg bolus, then 25 mcg/hr |
25 mcg/hr |
Q 15 min |
150 mcg/hr, Target RASS (-)2 to (-)3, or pain level 4-5. |
| Furosemide |
10 mg/hr |
20 mg/hr |
Q 60 min |
160 mg/hr |
| Hydromorphone |
2mg bolus, then 0.5 mg/hr |
0.5 mg/hr |
Q 15 min |
4 mg/hr, Target RASS (-)2 , or pain level 4-5. |
| Insulin |
Algorithm #2 |
See Critical Care Standard Orders |
Q 1 hour |
Target BG 140-180 |
| Labetolol |
2 mg/min |
2 mg/min |
Q 10 min |
300 mg/24 hrs |
| Lidocaine |
1 mg/kg bolus, then 1 mg/min |
0.5 mg/min |
Q 10 min |
4 mg/min |
| Lorazepam |
2 mg bolus, then 1 mg/hr |
1 mg/hr |
Q 60 min |
16 mg/hr, Target RASS (-)2. |
| Midazolam (Versed) |
2 mg bolus, then 2 mg/hr |
1 mg/hr |
Q 15 min |
0.2 mg/kg/hr, Target RASS (-)2. |
| Milrinone |
50 mcg/kg bolus, then 0.375 mcg/kg/min |
0.25 mcg/kg/min |
Q 15 min |
0.75 mcg/kg/min |
| Morphine |
2 mg bolus, then 1 mg/hr |
1 mg/hr |
Q 15 min |
15 mg/hr, Target RASS (-)2, or pain level 4-5. |
| Nicardipine |
5 mg/hr |
2.5 mg/hr |
Q 15 min |
15 mg/hr |
| Nitroglycerin |
5 mcg/min (0.1 mcg/kg/min) |
5 mcg/min (0.1 mcg/kg/min) |
Q 5 min |
200 mcg/min (2 mcg/kg/min) |
| Nitroprusside |
0.5 mcg/kg/min |
0.5 mcg/kg/min |
Q 5 min |
10 mcg/kg/min |
| Norepinephrine |
5 mcg/min (0.3 mcg/kg/min) |
5 mcg/min (0.1 mcg/kg/min) |
Q 3-5 min |
30 mcg/min (0.9 mcg/kg/min) |
| Phenylephrine |
50 mcg/min |
20 mcg/min |
Q 2-5 min |
200 mcg/min |
| Propofol |
5 mcg/kg/min |
5 mcg/kg/min |
Q 5 min |
Target RASS (-)2, or 60 mcg/kg/min. |
| Rocuronium |
0.8 mg/kg bolus, follwed by 8 mcg/kg/min |
0.8 mcg/kg/min |
Q 5 min |
10 mcg/kg/min, or Target Train of Four. |
| Vasopressin (shock) |
0.01 units/min |
0.01 units |
Q 15 min |
0.04 units/min |
| Vecuronium |
0.1 mg/kg bolus, then 0.9 mcg/kg/min |
0.3 mcg/kg/min |
Q 5 min |
1.5 mcg/kg/min, or Target Train of Four. |
