When should you order an arterial blood gas?

Arterial blood gas analysis is used to evaluate oxygen and carbon dioxide gas exchange and acid-base status.

General indications in severely ill adults usually include pathophysiologic abnormalities that can alter gas exchange or acid-base disturbances.

Indications for ABG

ABGs are frequently used for the following:

  • To identify and monitor acid-base disturbances
  • To measure the partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2)
  • To assess the response to therapeutic interventions (eg, insulin in patients with diabetic ketoacidosis)
  • To detect and quantify the levels of abnormal hemoglobins (eg, carboxyhemoglobin and methemoglobin)
  • To get a blood sample in an acute emergency setting when venous sampling is not feasible (most tests can be performed from an arterial sample)
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