Patients with MGUS will require regular follow-up visits because of the risk this condition will progress to multiple myeloma
“Monoclonal gammopathy of undetermined significance (MGUS) is present in approximately 2%–3% of the white population older than 50. It is associated with a risk of progression to multiple myeloma at a rate of 1% per year. Most patients diagnosed with MGUS should be reevaluated in 6 months with a medical history, physical examination, CBC, calcium and creatinine levels, and serum electrophoresis, and then annually thereafter.” ABFM
Further Reading / Reference
Protein electrophoresis and immunofixation for the diagnosis of monoclonal gammopathies. JAMA 2014;312(20):2160-2161.