| Type of Cancer | Notes | |
| Hypercalcemia | squamous cell carcinomas. | Up to 80% of cases are due to secretion of parathyroid hormone-related protein |
| Hypercalcemia | Breast cancer, lymphomas, and multiple myeloma | These may cause hypercalcemia as a result of osteolytic activity at the site of the metastasis. |
| Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) | – Small cell carcinoma of the lung – Prostate Cancer. |
-SCC of the lung is a major cause of SIADH -Prostate cancer can also cause SIADH |
| Cushing syndrome. | Thyroid Cancer | thyroid cancer can cause Cushing syndrome. |
Hypercalcemia due to malignancy has a poor prognosis.