Proton pump inhibitors (PPIs)

Long-term PPI use increases the risk of: 

1. Clostridium difficile-associated diarrhea.
2. Other enteric infections
3. Osteoporosis and Osteoporosis fractures.
4. Fractures (of the Hip, wrist, and spine)
5. Community-acquired pneumonia
6. Hypomagnesemia
7. Cardiac events when coadministered with clopidogrel.
8. Vitamin B12 Deficiency.
9. Affect absorption of other vitamins and minerals including iron and folate.

Reference
Am Fam Physician 2012;86(1):66-70
Ann Fam Med 2011;9(3):200–202