| Mechanism |
Symptoms |
Signs |
| Slowing of metabolic processes |
- Fatigue and weakness
- Cold intolerance
- Dyspnea on exertion
- Weight gain
- Cognitive dysfunction
- Mental retardation (infantile onset)
- Constipation
- Growth failure
|
- Slow movement and slow speech
- Delayed relaxation of tendon reflexes
- Bradycardia
- Carotenemia
|
| Accumulation of matrix substances |
- Dry skin
- Hoarseness
- Edema
|
- Coarse skin
- Puffy facies and loss of eyebrows
- Periorbital edema
- Enlargement of the tongue
|
| Other |
- Decreased hearing
- Myalgia and paresthesia
- Depression
- Menorrhagia
- Arthralgia
- Pubertal delay
|
- Diastolic hypertension
- Pleural and pericardial effusions
- Ascites
- Galactorrhea
|
